case report

Use of Silanols Associated with Aesthetic Treatments for Skin Rejuvenation in Menopausal Women

Luisa Wolpe*, Rodrigo Granzoti, Suellen Becher, Emanuel Muller

Researcher and Techno-Scientific Advisor, Aqia/Biotec, São Paulo, Brazil

*Corresponding authors: Luisa Wolpe, Researcher and Techno-Scientific Advisor, Aqia/Biotec, São Paulo, Brazil

Received Date: 08 March 2023

Accepted Date: 13 March 2023

Published Date: 15 March 2023

Citation: Wolpe L, Granzoti R, Becher S, Muller E (2023) Use of Silanols Associated with Aesthetic Treatments for Skin Rejuvenation in Menopausal Women. Ann Case Report. 8: 1212. DOI:https://doi.org/10.29011/2574-7754.101212

Introduction

Menopause is a phenomenon linked to the decline of ovarian activity. In this phase, the woman reduces the synthesis of sex hormones, which can compromise the function of various tissues. The skin is one of the structures affected by menopause, and hypoestrogenism intensifies the aging effects of skin tissue. Estrogen plays a key role in the synthesis of the extracellular matrix, and its absence leads to skin atrophy [1]. Nutritional strategies, cometary and aesthetic procedures for treating mature skin can greatly improve the appearance of aged skin [2,3]. The use of organic silicon, oral and topical, has proven effective in controlling aging, mainly by elevating collagen synthesis [4,5]. Recently, fractional radiofrequency (FFR) has gained momentum as the latest generation in combined treatments for skin rejuvenation. This technique uses minimally invasive micro-needles or electrode pins to target the dermal region. The thermal injury emitted by the micro-needles denatures collagen fibres and triggers tissue repair mechanisms [6,7]. This study aimed to evaluate the efficacy of fractional radiofrequency on the increase of dermal thickness and improvement of skin aesthetic parameters in post-menopausal women. This is a case study in which six women, all menopausal, aged between 46 and 63 years, were submitted to fractional radiofrequency, with a fractionated electrode with 25 needles of 1mm penetration, once every 30 days for 60 days.

The women were divided into three groups with three different treatments. The first OR + ST group made oral use of 200mg of orthosilicic acid stabilized in marine collagen, together with 5% methylsilanol manuronate, applied directly to the face region, twice a day (morning and evening). The second OS group received only the oral supplementation of 200mg of orthosilicic acid stabilized in marine collagen. The third ST group used only 5% methylsilanol manuronate applied directly to the face twice a day (morning and evening). All women underwent ultra-sonographic evaluation of the mentonian and malar regions of the left and right face. Three measurements of the regions (M1, M2, M3) were taken, obtaining the average dermal thickness of the skin in millimetres. The evaluation was done at the beginning of treatment (T0) and after 60 (T2) days of intervention. In the OR + ST group, there was an average increase of 0.40 mm in the dermal thickness of the left malar region, which represents an increase of 59.6% between T0 and T1. In the right malar region, there was a mean increase of 0.35 mm in dermal thickness, representing a 44.6% increase between T0 and T1. In the left mental region, there was a mean dermal thickness increase of 0.05 mm, representing a 3.8% increase between T0 and T1. In the right mental region, there was a mean dermal thickness increase of 0.22 mm, representing a 16.2% increase between T0 and T1 (Figure 1 and 2). The overall increase after the intervention period was 0.25 mm, representing a 31% increase in dermal thickness.

 

Figure 1: Right and left malar and mentonian evaluation by ultrasound imaging after oral and topical silicon in OR + ST group.

 

Figure 2: Right and left malar and mentonian evaluation by ultrasound imaging before oral and topical silicon in OR + ST group.

In the OR group, there was an average increase of 0.08 mm in dermal thickness in the left malar region, representing a 7.2% increase between T0 and T1. In the right malar region, there was a mean increase of 0.21 mm in dermal thickness, representing a 22.4% increase between T0 and T1. In the left mental region, there was a mean reduction of 0.03 mm in dermal thickness, representing a decrease of 0.9% between T0 and T1. In the right mental region, there was a mean increase of 0.3 mm in dermal thickness, representing a 23% increase between T0 and T1 (Figure 3 and 4). The overall increase after the intervention period was 0.14 mm, representing a 12.9% increase in dermal thickness.

 

Figure 3: Right and left malar and mentonian evaluation by ultrasound imaging after oral and topical silicon in OR group.