Annals of Case Reports (ISSN: 2574-7754)

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Short Term of Oral and Topical Use of Organic Silicon in Increasing Dermal Thickness: A Case Report.

Luisa Wolpe*, Rodrigo Granzoti, Maria Barbosa

Researcher and Techno-Scientific Advisor, Aqia/Biotec, São Paulo, Brazil

*Corresponding author: Luisa Wolpe, Researcher and Techno-Scientific Advisor, Aqia/Biotec, São Paulo, Brazil

Received Date: 26 September 2022

Accepted Date: 29 September 2022

Published Date: 03 October 2022

Citation: Wolpe L, Granzoti R, Barbosa M (2022) Short Term of Oral and Topical Use of Organic Silicon in Increasing Dermal Thickness: A Case Report. Ann Case Report. 7: 972. DOI: https://doi.org/10.29011/2574-7754.100972

Abstract

Menopause is an age-related factor that profoundly alters the structures and quality of the skin. In this study, researchers tested the oral supplementation of organic silicon (200mg) and topical use of silicon (5%).

Three post-menopausal women were recruited and divided into three groups: oral use, topical use, and oral and topical use. The treatment lasted for 30 days. Ultrasound imaging tests were performed to assess dermal thickness of the skin in four distinct regions of the face. After 30 days of treatment, was observed an improvement in the dermal thickness in the three treatments, but the most expressive results was observed in the woman who used oral and topical use. Thus, the association of organic silicon may be promising in improving skin quality associated with menopause.

Introduction

The skin tissue undergoes profound changes during the aging process. Anatomical and histomorphological alterations show a reduction in dermal thickness and decrease in collagen fibers that clinically manifest themselves with wrinkles formation in the skin [1]. Some strategies aim to reverse this process. Nowadays, dermatologists have available many anti-aging strategies, including preventive measurements, cosmetological strategies, invasive procedures, and oral and topical therapeutic agents [2]. Silicon (Si) has an important role in the maintenance of numerous body tissues [3]. In connective tissues, this nutrient maintains the integrity of the extracellular matrix components [4]. In the skin, silicon deprivation reduces hydroxyproline synthesis and can affect collagen content in the tissue [5]. Thus, knowing the importance of silicon, this case report aimed to evaluate the dermal thickness and the improvement of the aesthetic parameters of the skin after oral supplementation and the topical use of Si.

Case Report

In this case report, three women, all menopausal, aged between 57 and 67 years, underwent three different interventions. The first woman took orally, once a day, 200mg of organic silicon stabilized in marine collagen (OS) orally. The second woman, applied topically to the face 5% methylsilanol manuronate (ST) twice a day (morning and night). The third woman took orally, once a day, 200mg of organic silicon stabilized in marine collagen orally and applied topically to the face, twice day (morning and night), 5% methylsilanol manuronate (OS + ST). All women underwent ultrasound evaluation of the left and right mentonian face regions. Three measurements of the chin regions (M1, M2, and M3) were taken, obtaining the average skin dermal thickness in millimeters. Ultrasound assessments were performed in October 2021, one at the beginning of the month (T0) and another after 30 days (November 2021) of intervention (T1).

An increase in dermal thickness was observed in both treatments. In the OS + ST, there was an increase of 21% in the right mental region (T0: 1.4 mm; T1: 1, 7 mm) and 20% (T0: 1.5 mm; T1: 1, 8 mm) in the left region (Table 1 and Figure 1).

Region

Intervention

M1

M2

M3

MEDIA

Right

14/10/2021

1,3 mm

1,4 mm

1,5 mm

1,4 mm

16/11/2021

1,7 mm

1,8 mm

1,8 mm

1,7 mm

Left

14/10/2021

1,6 mm

1,5 mm

1,4 mm

1,5 mm

16/11/2021

1,8 mm

1,7 mm

1,8 mm

1,8 mm

M1, M2, M3 - analysis point.

Table 1: Changes in dermal thickness in the mental region after oral and topical silicon.