case report Treatment of Acrodermatitis Continua of Hallopeau with Guselkumab in a Patient without IL36RN Mutations: A Case Report and a Literature Review
Jianfeng Zheng, Ying Zhang, Yangfeng Ding*, Yunlu Gao*
Department of Dermatology, Shanghai Skin Disease Hospital; Institute of Psoriasis, Tongji University School of Medicine, Shanghai, China
*Corresponding author’s: Yangfeng Ding and Yunlu Gao, Department of Dermatology, Shanghai Skin Disease Hospital; Institute of Psoriasis, Tongji University School of Medicine, 1278 Baode Road, Jingan District, Shanghai 200443, China
Received Date: 28 October 2022
Accepted Date: 01 November 2022
Published Date: 04 November 2022
Citation: Zheng J, Zhang Y, Ding Y, Gao Y (2022) Treatment of Acrodermatitis Continua of Hallopeau with Guselkumab in a Patient without IL36RN Mutations: A Case Report and a Literature Review. Ann Case Report. 7: 1017. DOI: https://doi.org/10.29011/2574-7754.101017
Abstract
Acrodermatitis continua of Hallopeau (ACH) is a rare, sterile pustular psoriasis variant refractory to many conventional treatments. The eruption typically occurs after local trauma or infection; other etiologies include neural, inflammatory, and genetic causes. Herein, we reported a single case of a 61-year-old patient with ACH that was successfully treated with guselkumab for 76 weeks. At first, the patient was misdiagnosed with onychomycosis. Due to the worsening of nail lesions, the patient was admitted to our hospital. Subungual pustules were observed, and multiple cultures of the pustules were all negative. Thus, a diagnosis of ACH was made. The patient was treated with 100 mg guselkumab post admission. Four weeks after the first infusion, the patient showed minimal improvement; eight weeks after the second infusion, the patient showed clinical improvement and was still under treatment. Meanwhile, whole exome sequencing was performed for our patient, revealing no rare coding variant in IL36RN, CARD14, or AP1S3. This case report is associated with a review of recent data on ACH with biological treatments and gene mutations.
Keywords: Acrodermatitis continua of Hallopeau; Pustular psoriasis; Guselkumab; IL36RN; Case report