case report

Successful Hematological Treatment of Monoclonal Gammopathy with Ocular Significance (MGOS)

Kitti Kormányos1*, Achim Langenbucher2, Zoltán Zsolt Nagy1, Zsolt Lázár3, Aryan Hamed3, Gábor Mikala4, Nóra Szentmáry1,5

1Department of Ophthalmology, Semmelweis University, Budapest, Hungary

2Experimental Ophthalmology, Saarland University, Homburg/Saar, Germany

3Petz Aladár University Teaching Hospital, Győr, Hungary

4South-Pest Central Hospital – National Institute for Hematology and Infectious Diseases, Department of Hematology and Stem Cell-Transplantation, Budapest, Hungary

5Dr. Rolf M. Schwiete Center for Limbal Stem Cell and Congenital Aniridia Research, Saarland University, Homburg/Saar, Germany

*Corresponding author: Kitti Kormányos, Department of Ophthalmology, Semmelweis University, Budapest, Hungary

Received Date: 14 November 2022

Accepted Date: 17 November 2022

Published Date: 21 November 2022

Citation: Koramanyos K, Langenbucher A, Nagy ZZ, Lazar Z, Hamed A, et al (2022) Successful Hematological Treatment of Monoclonal Gammopathy with Ocular Significance (MGOS). Ann Case Report 7: 1044. DOI:


Background: The most common ocular symptom of monoclonal gammopathy is the appearance of corneal opacities. Our goal is to present a case with successful haematological treatment of monoclonal gammopathy with ocular significance (MGOS).

Case Report: Our patient was diagnosed with MGOS, with increasing corneal opacification and decreasing visual acuity. Following 4 cycles of plasma-cell-directed bortezomib and dexamethasone treatment (1,3mg/m2 bortezomib subcutaneously and 20 mg dexamethasone orally), most of the corneal opacities disappeared or decreased in size and best corrected visual acuity of the patient increased.

Conclusion: In summary, in monoclonal gammopathy with ocular significance, plasma-cell-directed bortezomib-dexamethasone treatment may successfully decrease or diminish MGOS. The mechanism of corneal opacification and its disappearance has to be further analysed.

Keywords: Monoclonal gammopathy; Ocular significance; MGUS; MGOS

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