Case Report Seronegative HCV Infection and Seroreversion of an HIV Antibody-Positive AIDS Patient
by Rosamaria Tedeschi1*, Giancarlo Basaglia1, Michele Spina1, Ornella Schioppa2
1Microbiology and Virology Unit, Santa Maria degli Angeli General Hospital, Azienda Sanitaria Friuli Occidentale (ASFO) Pordenone, Italy
2Division of Medical Oncology and Immune-related Tumors, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy
*Corresponding author: Rosamaria Tedeschi, Microbiology and Virology Unit, Santa Maria degli Angeli General Hospital, Azienda Sanitaria Friuli Occidentale (ASFO) Pordenone, Italy
Received Date: 18 August 2025
Accepted Date: 21 August 2025
Published Date: 25 August 2025
Citation: Tedeschi R, Basaglia G, Spina M, Schioppa O. (2025). Seronegative HCV Infection and Seroreversion of an HIV Antibody-Positive AIDS Patient. Ann Case Report. 10: 2383. DOI:10.29011/2574-7754.102383
Abstract
We describe the case of an HIV+ patient who showed an abnormal ALT levels and was found to have high HCV RNA viral load (1140000 UI/ml) whereas HCV antibodies screening was negative. Newsworthy, this patient, with a stable immunological status, also experienced spontaneous loss of HIV antibodies (seroreversion).
Our case report shows a complex interplay of both viral and host factors leading to rare phenomena, like seronegative HCV infection and HIV seroreversion. A particular attention should be given to the HCV monitoring in patients at risk of HIV-related infections.
Keywords: HCV; HIV; Seronegative HCV; HCV/HIV Coinfection; HIV Seroreversion.
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