Research Article Role for Genes Involved in β-Cell Function in Type 2 Diabetes
Mitsuo Futamura, Tomoya Nakai*, Goichi Nishida, Tamotsu Nishimura
Department of health sciences, Osaka City University, Japan
*Corresponding author: Tomoya Nakai, Department of health sciences, Osaka City University, 28-4, Japan
Received Date: 04 June, 2023
Accepted Date: 23 June, 2023
Published Date: 27 June 2023
Citation: Futamura M, Nakai T, Nishida G, Nishimura T (2023) Role for Genes Involved in β-Cell Function in Type 2 Diabetesme. J Diabetes Treat 8: 10120. https://doi.org/10.29011/2574-7568.010120
Abstract
We examined 152 SNPs in 71 candidate genes for association with diabetes status and related phenotypes in 2,134 Caucasians in a case-control study and an independent quantitative trait (QT) cohort in the United Kingdom. Polymorphisms in five of 15 genes (33%) encoding molecules known to primarily influence pancreatic β-cell function—ABCC8 (sulphonylurea receptor), KCNJ11 (KIR6.2), SLC2A2 (GLUT2), HNF4A (HNF4α), and INS (insulin)—significantly altered disease risk, and in three genes, the risk allele, haplotype, or both had a biologically consistent effect on a relevant physiological trait in the QT study. This study additionally demonstrates that the systematic examination of panels of biological candidate genes in large.
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