Review Article Restrictive vs Liberal Red Blood Cell Transfusion Strategy in Patients with Acute Leukemia: A Systematic Review and Meta-analysis
by Xinying Quan1, Yao Pu2, Hone Deng3, Yujie Zhang1*
1Department of Blood Transfusion, Guizhou Branch of Beijing Jishuitan Hospital, Guiyang, Guizhou 550014, China
2Department of Pharmacy, Guiyang Second People's Hospital, Guiyang, Guizhou 550081, China
3Laboratory Department, People's Hospital of Baiyun District, Guiyang, Guizhou 510080, China
*Corresponding author: Yujie zhang, Guizhou Branch of Beijing Jishuitan Hospital, No.206, Sixian Street, Baiyun District, Guiyang, Guizhou 550014, China
Received Date: 26 January 2026
Accepted Date: 09 February, 2026
Published Date: 13 February, 2026
Citation: Quan X, Pu Y, Deng H, Zhang Y (2026) Restrictive vs Liberal Red Blood Cell Transfusion Strategy in Patients with Acute Leukemia: A Systematic Review and Meta-analysis. Int J Nurs Health Care Res 9:1697. DOI: https://doi.org/10.29011/2688-9501.101697
Abstract
Objectives Determine the relative efficacy and safety of restricted blood transfusion (RBT) and liberal blood transfusion (LBT) strategies. Methods Our quantitative meta-analysis initially explored appropriate transfusion strategies for this specific disease. Seven studies, encompassing 1004 patients with acute lymphoblastic leukemia, were included. Results The findings indicate that restrictive transfusion strategies can significantly decrease the overall transfusion volume in acute leukemia patients (95% CI: 2.23-0.38, P=0.006), without compromising treatment efficacy or safety. This approach offers a more resource-efficient alternative to the liberal blood transfusion strategy during anemia treatment. Conclusion Restrictive blood transfusion strategy effectively reduce the total transfusion volume without compromising treatment efficacy or safety in patients with acute leukemia. This approach offers a more resource-efficient way alternative to liberal transfusion strategy in the management of anemia during the treatment of the disease.
Keywords: Acute leukemia; Restrictive blood transfusion; Liberal blood transfusion; meta-analysis
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