Research Article Phenol as a Breath Marker for Hemodialysis of Chronic Kidney Disease Patients
by Isabell Eickel1*, Anne-Christine Zygmunt1, Frank Streit2, Björn Tampe3, Nils Kunze-Szikszay4, Thorsten Perl1
1Department of General, Visceral and Pediatric Surgery, University Medical Center Gottingen, Gottingen, Germany
2Department of Clinical Chemistry, University Medical Center Gottingen, Gottingen, Germany
3Department of Nephrology and Rheumatology, University Medical Center Gottingen, Gottingen, Germany
4Department of Anesthesiology, University Medical Center Gottingen, Gottingen, Germany
*Corresponding author: Isabell Eickel, Department of General, Visceral and Pediatric Surgery, University Medical Center Gottingen, Gottingen, Germany
Received Date: 28 March, 2024
Accepted Date: 06 April, 2024
Published Date: 08 April, 2024
Citation: Eickel I, Zygmunt AC, Streit F, Tampe B, Szikszay NK, et al. (2024) Phenol as a Breath Marker for Hemodialysis of Chronic Kidney Disease Patients. J Med Biomed Discoveries 6: 123. https://doi.org/10.29011/2688-8718.100023
Abstract
Background: We aimed to identify biomarkers in breath analysis with MCC-IMS to monitor the haemodialysis for CKD patients fast and non-invasive. Material & methods: Six patients’ breath was analysed via MCC-IMS before and after dialysis and compared to blood plasma samples analysed via UPLC-FLD for potential renal failure biomarkers. Additionally, breath from six healthy control persons was analysed. Results: Phenol was found as a breath marker for CKD. For three patients the phenol concentration in breath and plasma was elevated before and decreased during dialysis and reached values in the range of healthy control persons. Conclusion: This study shows that the measurement of phenol via breath analysis could be used to monitor the haemodialysis for CKD-patients and might also be usable for the calculation of haemodialysis dose in the future.
Keywords: Chronic kidney disease; Breath analysis; Breath marker; Ion mobility spectrometry; MCC IMS; phenol
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