Case Report Diffused Malignant Peritoneal Mesothelioma Complete Pathologic Response after Combination of Cytoreductive Surgery (CRS) Plus Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Nivolumab
by Ching-Hsien Ling1, Toshiyuki Kitai3, Kenya Yamanaka5, Haruaki Ishibashi3, Takuji Fujita3, Yang Liu3, Satoshi Wakama3, Syouzou Sako3, Yasuo Hirono3, Keizou Taniguchi6, Daisuke Fujimoto6, Yen-Cheng Chen1,7, Yutaka Yonemura2-4*
1Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan
2Asian School of Peritoneal Surface Malignancy Treatment, Kyoto City, Kyoto Prefecture, Japan
3Department of Regional Cancer Therapy, Peritoneal Dissemination Center, Kishiwada Tokushukai Hospital, Kishiwada City, Oosaka Prefecture, Japan
4Department of Regional Cancer Therapy, Peritoneal Dissemination Center, Kusatsu General Hospital, Japan
5Department of Surgery, Hyogo Prefectural Amagasaki General Medical Center, Japan
6Department of Surgery, Mizonokuchi Hospital, Teikyo University, School of medicine, Kawasaki, Kanagawa, 213-8507, Japan
7School of Medicine, Tzu Chi University, Hualien, Taiwan
*Corresponding author: Yutaka Yonemura, Representative of Asian School of Peritoneal Surface Malignancy Treatment. Department of Regional Cancer Therapies, Peritoneal Surface Malignancy Treatment Center, Kishiwada Tokushukai Hospital, Osaka, Japan
Received Date: 08 August 2023
Accepted Date: 14 August 2023
Published Date: 16 August 2023
Citation: Ling CH, Kitai T, Yamanaka K, Ishibashi H, Fujita T, et al (2023) Diffused Malignant Peritoneal Mesothelioma Complete Pathologic Response after Combination of Cytoreductive Surgery (CRS) Plus Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Nivolumab. Arch Surg Clin Case Rep 6: 203. https://doi.org/10.29011/2689-0526.100203
Abstract
Malignant mesothelioma is a rare malignancy. Most occurred in the pleural cavity. The peritoneal cavity is the second frequent space. After diagnosis, surgical resection is recommended for restrictive condition. Systemic treatments were recommended for diffusely distributed cases but the prognosis is very poor. Here we report a case of diffused disseminated MPM treated by staged CRS plus HIPEC and post-operative nivolumab monotherapy. At second scheduled operation, we found tumor response well to treatment and final pathologic exam proved to be complete response.
Keywords: Malignant Peritoneal Mesothelioma; Cytoreductive Surgery; Hyperthermic Intraperitoneal Chemotherapy; Nivolumab
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