Biological Basis of Transplant Failure
Abbas Alnaji*
Department of Consultant Neurosurgeon, Alsadir Medical City, Najaf, Iraq
*Corresponding
author: Abbas Alnaji, Department of Consultant Neurosurgeon,
Alsadir Medical City, Najaf, Iraq.
Tel: +9647700059052; Email: abbasalnaji@yahoo.com
Received
Date: 01 August, 2018; Accepted Date: 09 August, 2018; Published
Date: 17 August, 2018
Citation: Alnaji A (2018) Biological Basis of
Transplant Failure. Cytol Histol Rep: CHR-101.
DOI: 10.29011/CHR-101.100001
Description
Tissue
and organ transplant is a big and wide field in medicine and surgery with so
progressive prospects that some intend to transplant the head many decades
after heart and many other vital organs transplantation. This art is of a solid
need both of the basic sciences which is built on to make it walk on a proper
platform and the mankind necessities to overcome body defects of any kind throughout
its life journey. No one denies the progressive success in results which was
very daring from the start. Still many failures and not optimal results to date
Inspite of the vast and painful efforts. To date the core in this inefficiency
is the rejection from the recipient side due to tissue identity which partially
do not coupe the that of donor provided all others are excluded. Still, one of
the excluded factors is working but in a hiding and wicked manner. It is the infection.
Now I do not want to discuss the routine and slandered acts pre-, intra- and
post transplantation of any tissue or organ I know each has his/her own art and
tricks. The infection I want to give attention to is the intracellular
bacterial infection. A fact of a long-standing cells being inhabited by some
one or more kind of fifteen intracellular bacteria like Brucella, Salmonella, Tuberculosis
and the others. Either in one side (donor/recipient) or the both. So under a
fact of such entity do we think or expect that our transplant will be
completely grown in a healthy environment!!?? This fact may be the cause for
the failures or the weak results in centers whatever where after the HLA
matching being accepted. we may extend that this HLA is not the real factor in
rejection even!! This vision was born through the results of my work on the
biological basis of the Neurosurgical pathologies where after the clinical
based trials then the admit of PCR into service and lately the Micro-array
screen for DNA detection of the tissue samples for the intracellular bacteria
showed more than one imagine the incidence of these intracellular bacteria into
the patients cells who were suffering from diseases referred to as of unknown
etiologies and being treated symptomatically or with palliative medicines like
corticosteroids. Before the writing of these words the lab gave me a phone call
to tell me that one of my patients with very long history of sufferings of so
many kinds and so many failed regimens, here Trapezius muscle open biopsy
showed two bacteria Tuberculosis and H. influenza in one sample with real time PCR for Brucella alone and Micro-array screen
for eight bacteria ( I am very active to cover others as a screen test but this
is a technical difficulty mean while), the astonishing in that the result is
negative for Brucella while my
impression on her condition was a chronic active Brucellosis and being treated
for that with more than excellent results, here clinical picture that I were
consulted for was an annoying scalp big suppurative boils that make here cannot
put her head on pillow, the successive days showed dramatic improvements in
many, many, other old complaints !!