A Case of Atopic Dermatitis That Healed Virtually Completely After A Number of Intradermal Injections with A Non-Specific Antigen Solution
Kimihiko Okazaki
Okazaki Medical Clinic, Ukyoku, Kyoto, Japan
*Corresponding author: Kimihiko Okazaki, Okazaki Medical Clinic, Ukyoku, Kyoto, Japan;
E-mail: ma13081x@ma1.seikyou.ne.jp
A 3-year-old boy, who had had an atopic
dermatitis since shortly after birth, visited my clinic on October 24, 2012
(Figure 1). I started injecting him with 0.1ml of 10 to the 25 fold-diluted
(with saline) Neurotropin, a product of Nippon Pharmaceutical Company, Osaka,
Japan, consisting of extract of rabbit skin inflamed with inoculation of
Vaccine virus intradermally alternately on both upper arms at 2~3 day
intervals. Immediately after I repeated the injection 38 times, the patient
scratched his own body and made the skin condition considerably worse. I
started using 0.1ml of 10 to the 32 fold-diluted Neurotropin to accommodate the
worsened skin condition. After I treated the patient with 111th injection with
the more diluted solution, he claimed of a worse itchiness and a more
erythematous skin color. Then I started using 0.1ml of 10 to the 36
fold-diluted Neurotropin. After a 20-time repetition of this injection, I
started using 0.1ml of 10 to the 39 fold-diluted Neurotropin because his skin
condition became worse again presumably due to increase in the patient’s
sensitivity to the injected antigen. After a 7-time repetition of it, the
patient’s cheek skin became worse. Then, I started using 0.1ml of 10 to the 44
fold-diluted Neurotropin. After an 83-time repetition of that, his skin
condition became worse, again. I started using 0.1ml of 10 to the 47
fold-diluted Neurotropin. After a 38-time repetition of that, his skin
condition became worse. I started using 0.1ml of 10 to the 50 fold-diluted
Neurotropin. After a 10-time repetition of it, the patient claimed itchiness at
his right-side abdomen. I started using 0.1ml of 10 to the 66 fold-diluted
Neurotropin. After a 4-time repetition of it, his skin condition became worse.
I started using 0.1ml of 10 to the 69 fold-diluted Neurotropin.
After a 31-time repetition, his skin became neither better nor worse. Then, I
started using 0.1ml of 10 to the 75-fold diluted Neurotropin.
Currently, he keeps receiving it. At the 226th injection, I
changed the injection-site from the upper arm to the navel-edge because the
latter has a thicker skin so that the duration-time of the injected solution in
the skin becomes longer resulting in a quantitative increase in the synthesis
of the non-specific antibody (Figure 2).
Figure 1
Figure 2
© by the Authors & Gavin Publishers. This is an Open Access Journal Article Published Under Attribution-Share Alike CC BY-SA: Creative Commons Attribution-Share Alike 4.0 International License. Read More About Open Access Policy.