Educational Research Applications (ISSN: 2575-7032)

review article

Teaching Students Synthesizing Molecules Mimicking an Existing Drug against Covid-19

Moges Abebe1*, Lashan Eloise Knowles1, Bisrat Hailemeskel2

1Department of Biological and Physical Sciences, Saint Augustine University, Raleigh, NC, USA

2Department of Clinical & Administrative Pharmacy Sciences, College of Pharmacy, Howard University, NW Washington, DC, USA

*Corresponding author: Moges Abebe, Department of Biological and Physical Sciences, Saint Augustine University, Raleigh, NC 27610, NC, USA

Received Date: 26 May, 2020; Accepted Date: 01 June, 2020; Published Date: 06 June, 2020

Abstract

End of semester organic chemistry course projects are valuable learning assessment tools while giving students a creative opportunity and sparking interest for further research investigations. The purpose of this year’s project was to teach students how to synthesize a molecule that potentially mimics an existing drug that works against the COVID-19. The available drugs chosen for the project are those that are proposed to work either by prohibiting the easy entry of the virus into respiratory tissues or those who deprive the virus’s ability to reproduce once they enter the cell. An investigative search in historical literature and the current conditions of the virus enabled students to create a unique and innovative product that requires a cumulative learned knowledge. History has shown that when a new virus becomes pandemic it takes time for researchers to create a drug, test the results, and gets approved by the Food and Drug Administration (FDA) for public availability. If given an opportunity, students can offer their untapped imagination and resourcefulness to produce the groundwork for a drug that will fight the COVID-19 virus. In this project, three drugs that are in clinical trials against Covid-19 were studied. Their structure activity and active functional group were reviewed. Based on their structure using their proposed active functional group, a chemical molecule was synthesized using phenol as a starting molecule and adding butanoic acid with an amino group as an attachment. The final functional groups in the molecule are a hydroxide group, benzene ring, amine, an ester, and two methyl groups. By mimicking the active functional groups in drugs that are in clinical trail at the time this review, we hopefully achieved our goal of teaching students a strategy that potentially leads to new drug discovery.


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