Reports on Global Health Research (ISSN: 2690-9480)

research article

Association between Optical Signal Derived Aortic Augmentation Index and Cardiovascular Risk Factors in Healthy Volunteers

Marika Pikta1,3*, Margus Viigimaa2,3, Kristjan Pilt3, Kristina Kööts3, Kalju Meigas3

1Laboratory, North Estonia Medical Centre, Tallinn, Estonia

2Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia

3Department of Health Technologies, Tallinn University of Technology, Tallinn, Estonia

*Corresponding author: Marika Pikta, Department of Health Technologies, Tallinn University of Technology, Tallinn, Estonia

Received Date: 05 March, 2020; Accepted Date: 19 March, 2020; Published Date: 24 March, 2020


Background: The aim of this study was to determine whether the photoplethysmographic signal derived Aortic Augmentation Index (PPGAIxao) can be used as an alternative method for cardiovascular risk estimation. The relationship between PPGAIxao and the traditional cardiovascular risk factors were investigated on apparently healthy subjects.

Methods: The Photoplethysmographic (PPG) signal was registered from right hand index finger of healthy volunteers. The Arteriograph device was used as a reference for the pulse wave analysis parameters and aortic pulse wave velocity measurements. The HDL-cholesterol, LDL-cholesterol, total cholesterol and triglycerides from collected peripheral venous blood specimens were measured. The relationships between the results of arterial stiffness related parameters and the traditional cardiovascular risk factors were analyzed.

Results: Our data showed the strong correlation between Arteriograph and PPG signal derived augmentation indices (r=0.78). The PPGAIxao values were averagely 7% higher than Arteriograph estimated aortic Augmentation Index (AIxao). The PPGAIxao and AIxao showed positive correlation or did not correlate with other cardiovascular risk parameters. Both derived augmentation indices were higher in case of higher SCORE risk chart values and in case of subject groups with higher age.

Conclusion: It can be assumed that the optically estimated PPGAIxao could be considered in the future as one method for augmentation index and cardiovascular risk estimation. Future studies have to be carried out on actual patients, to improve the PPG waveform registration method.


Arterial Stiffness; Augmentation Index; Cardiovascular Risk Factors; Photoplethysmography; Pulse Wave Analysis; Pulse Wave Velocity

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