Journal of Surgery (ISSN: 2575-9760)

research article

The Utilization of a Topical Nitric Oxide Generating Serum in Aesthetic Medicine

Gregory Chernoff BSc, MD, FRCS(C)*

Private Practice, Chernoff Cosmetic Surgeons, Ascension St. Vincent Hospital, Indianapolis IN, USA

*Corresponding author: Gregory Chernoff, Private Practice, Chernoff Cosmetic Surgery, Ascension St. Vincent Hospital, Indianapolis IN, USA

Received Date: 18 August, 2020; Accepted Date: 24 August, 2020; Published Date: 28 August, 2020


Key Points:

1. A Nitric oxide serum can be safely formulated without the generation of nitric dioxide and is necessary for optimal cellular health.

2. Nitric oxide serum can be topically applied for many cosmetic purposes, and also has anti-inflammatory and ant-bacterial properties.

3. Nitric oxide is a free radical gas. It is produced endogenously and is synthesized from arginine by nitric oxide synthase.

4. Nitric oxide mediates vasodilation, inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adherence to endothelial cells. As a result, Nitric oxide is a potent vasodilator, and increases blood flow via capillary recruitment.

5. Topical Nitric Oxide Serum by itself, yields improvement in fine lines and wrinkles, and enhances the tone, texture of the skin.

6. When used prior to any other topical, the vasodilatory property primes the skin to enhance the absorption of other products.

Methods: One hundred patients were enrolled into a two center, multi-limb study. Ages ranged from 15 to 76 years. The effect of a Nitric Oxide generating topical serum was studied on 100 patients in two Centers between December 2018 and December 2019. There were 82 females and 18 males. The population consisted of 42 Caucasian, 18 Asian, 8 African American, 12 Hispanic, 14 Mediterranean, and 6 Indian patients.

Patients were enrolled under four categories: 1) Aging Skin; 2) Acne; 3) Scar Therapy; and 4) Wound Care. The Aging skin population utilized NO serum bid after cleansing. Photographs were taken monthly for 4-12 weeks. Linear analog scales were administered examining skin tone, wrinkles, clarity and color variation. No other products were used concomitantly.

The Active acne patients were divided into mild, moderate and severe states based on nodule and pustule counts. NO serum was applied am and pm after cleansing. Photographs were taken weekly for 4-12 weeks. Pustule and nodule counts were recorded weekly. NO serum was applied bid in the treatment of atrophic scars, striae, acne scars, hypertrophic scars post Needle Radiofrequency, and around the CO2 laser excised keloid scar beds. Photographs were taken weekly for 4-12 weeks. Several wound types were examined: Surgical incisions, healing surgical flaps, diabetic ulcers, and smoking induced, vascular compromised skin. NO serum was applied qid daily. Photographs were taken at 4, 8, and 12 weeks.

Results: The Aging skin population reported improvement in fine lines, wrinkles, pore size, skin tone and texture, coloration and oiliness. A high level of product satisfaction with significant improvement in self-esteem was noted. The Acne population showed a range in pustule and nodule reduction ranging from 20% to 84%. The average reduction was 68%. The Scar therapy population showed positive trends. The atrophic scar patients and those with striae improved the most. Softening of hypertrophic scar tissue was noted. Keloid wound beds healed anecdotally faster than non-treated patients. Improved vascularity is speculated. The Wound healing population without exception showed excellent results. Rhytidectomy, Blepharoplasty, and Rhinoplasty patients displayed less bruising, edema, and more rapid healing. Non-healing ulcers healed within 30-45 days. Revascularization was routinely evident in compromised flaps.

Conclusion: It is possible to deliver clinically relevant bioactive nitric oxide via a dual chamber NO generating delivery device. This Pilot Study shows valid proof of concept to warrant further IRB approved studies in the areas of aging skin, acne, wound healing and scar therapy.


Nitric oxide; Regenerative medicine; Topical applications

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