Journal of Oncology Research and Therapy (ISSN: 2574-710X)

research article

Polyploid Giant Cancer Cells are Involved in Paclitaxel-induced Chemotherapy Resistance via Neosis in Non-Small Cell Lung Cancer

Pan Sun, Haizhen Jin, Lili Guo, Xiaohua Yang, Na Zhang, Kai Wang, Ling Tian*

*Corresponding Author: Ling Tian, Department of Central Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Received Date: 25 August, 2021

Accepted Date: 29 September, 2021

Published Date: 05 October, 2021

Abstract

 Paclitaxel is widely used to treat cancer patients through the blocking of mitosis, yet results in formation of polyploidy giant cancer cells (PGCCs), which are generally believed to be non-dividing cells and involve in tumor recurrence in certain cancers, such as ovarian cancer, breast cancer and colorectal cancer, et al. However, there are few studies related to PGCCs in lung cancer. Herein, we observed PGCCs in tumor tissues of non-small cell lung cancer (NSCLC) patients and verified that paclitaxel could induce PGCCs in NSCLC cells in vitro. PGCCs was revealed to bud via neosis to form daughter cells, which have stronger ability of migration, proliferation and colony formation. PGCCs were also found to be not only associated with tumor heterogeneity but also contribute to paclitaxel resistance. These results suggested that PGCCs were closely related to chemotherapy resistance to paclitaxel, leading to tumor recurrence in NSCLC patients.

Keywords: Polyploid giant cancer cells; Neosis; Paclitaxel; Chemotherapy resistance; Non-small cell lung cancer


Page Views: 11165663