Background: Herbal medicinal
products containing extracts of saw palmetto berries (Serenoa repens) are used for treatment of Lower Urinary Tract
Symptoms (LUTS) because of Benign Prostatic Obstruction (BPO). Improvement of sexual dysfunctions was also
Methods: Here we performed a multicentric open label clinical study on 84
men to confirm its effects on LUTS/BPO on Slovenian population and this is only
the second study investigating the effect on sexual dysfunctions.
Results: In 6 months of treatment the International
prostate symptom score (IPSS) improved from 12.7 to 9.2 (p = 7.0×10-12)
and the quality of life score improved from 2.4 to 1.7 (p = 9.2×10-4).
Prostate-Specific Antigen (PSA) levels did not change. The proportion of
patients with unsatisfactory libido reduced from 26.5 % to 13.2 % (p=0.036)
during the therapy and a non-significant trend of reduction of erectile
dysfunction was observed.
Conclusion: Our results are in agreement with
the previous research on the efficacy of saw palmetto, but regarding the libido
and erectile dysfunction, further controlled studies are needed.
Keywords: Berries; Erectile Dysfunction; Libido; Saw Palmetto (Serenoa Repens); Slovenian Population
List of Abbreviations
BPE : Benign
BPH : Benign
BPO : Benign
ED : Erectile
IPSS : International
Prostate Symptom Score;
LUTS : Lower
Urinary Tract Symptoms;
PSA : Prostate-Specific
QoL : Quality