Journal of Diabetes and Treatment (ISSN: 2574-7568)

research article

Senna Leaves Treatment to Diabetics Improves Defence of Red Blood Cells and Other Diabetic Complications


Gupta BL1*, Saini GL2, Bharti AK2, Trilok K2


1Department of Zoology, JK College, LN Mithila University, Biraul, Darbhanga, Bihar, India

2School of Biotechnology, Jawaharlal Nehru University, New Delhi, India

*Corresponding author: Bihari Gupta, Department of Zoology, J.K. College, L.N. Mithila University, Biraul, Darbhanga, Bihar-847203, India. Tel: +918447795765; Email:

Received Date: 11 November, 2017; Accepted Date: 30 April, 2018; Published Date: 08 May, 2018

1.       Abstract

1.1.   Aims: Diabetes has been reported with constipation leading to the development of other diabetic were to treat diabetics with a new method of preparation of Senna leaves extract to control constipation and to observe the defence of red blood cells, liver dysfunction and other diabetic complications.

 1.2.   Methods: Senna leaves extract was prepared in hot water and orally administered to diabetics with constipation in 5 males and 4 females over the age of 50. This treatment was performed thrice a week in the 1st month, twice a week in the corresponding 2nd and 3rd months and once a week from 4th to 6th months. The defensive enzyme, the glutathione peroxidase was measured in the red blood cells along with the levels of reduced glutathione. The liver function test was performed by measuring AlaAT and AsAT levels. The other diabetic complications were also observed throughout the treatment.

 1.3.   Results: The diabetic persons were found to be vulnerable to skin infection particularly in the pelvic regions, backside, legs, etc. which were reversed to normal after six months of Senna leaves treatments. The neurological disorder like sustaining pain in legs was also recovered with the treatment. The stools quality also changed to normal. The physiological disorder like swelling of legs also improved by the treatment. The fasting glucose and glucose after meal remained to be in between 80-170 mg/dl of blood. In four of the diabetic persons who lost 15-20% of body weight, gained body weight by 7-10%. The percentage of glycosylated haemoglobin improved also and was found to be in normal range showing a long-term management of diabetes. The glutathione peroxidase decreased in red blood cells of diabetics by 20-30%, normalised after six months of treatment with Senna. The reduced glutathione found to be decreased in diabetics by 15-20%, normalised also. An increase in AlaAT in diabetic RBCs also got normalised after Senna treatment.

 1.4.   Conclusion: Senna leaves treatment to diabetics not only corrects the defence of red blood cells but also corrects skin infection, liver disorder, neurological disorder (pain in legs), physiological disorder (swelling in legs) and found to be a better alternative for a long-term management of diabetes even after treatment with antidiabetic drugs.

2.   Keywords: Px - Glutathione Peroxidase; GSH - Reduced Glutathione; GHb - Glycosylated Haemoglobin; AlaAT - Alanine Aminotransferase; AsAT - Aspartate Aminotransferase

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