Diabetes has been reported with
constipation leading to the development of other diabetic were to treat diabetics with a new method of preparation
leaves extract to control constipation and to observe the defence of red blood
cells, liver dysfunction and other diabetic complications.
leaves extract was prepared in hot water and orally administered to diabetics
with constipation in 5 males and 4 females over the age of 50. This treatment
was performed thrice a week in the 1st month, twice a week in the corresponding 2nd and 3rd months and once a week from 4th to 6th
months. The defensive enzyme, the glutathione peroxidase was measured in the
red blood cells along with the levels of reduced glutathione. The liver
function test was performed by measuring AlaAT and AsAT levels. The other diabetic complications were also observed
throughout the treatment.
The diabetic persons were found to
be vulnerable to skin infection particularly in the pelvic regions, backside,
legs, etc. which were reversed to normal after six months of Senna
leaves treatments. The neurological disorder like sustaining pain in legs was
also recovered with the treatment. The stools quality also changed to normal.
The physiological disorder like swelling of legs also improved by the
treatment. The fasting glucose and glucose after meal remained to be in between
80-170 mg/dl of blood. In four of the diabetic persons who lost 15-20% of body
weight, gained body weight by 7-10%. The percentage of glycosylated haemoglobin
improved also and was found to be in normal range showing a long-term
management of diabetes. The glutathione peroxidase decreased in red blood cells
of diabetics by 20-30%, normalised after six months of treatment with Senna.
The reduced glutathione found to be decreased in diabetics by 15-20%, normalised
also. An increase in AlaAT in diabetic RBCs also got normalised after Senna
leaves treatment to diabetics not only corrects the defence of red blood cells
but also corrects skin infection, liver disorder, neurological disorder (pain
in legs), physiological disorder (swelling in legs) and found to be a better
alternative for a long-term management of diabetes even after treatment with
2. Keywords: Px - Glutathione Peroxidase; GSH - Reduced Glutathione; GHb -
Glycosylated Haemoglobin; AlaAT - Alanine Aminotransferase; AsAT - Aspartate Aminotransferase