Emergency Medicine Investigations (ISSN: 2475-5605)


Allergic Reactions Caused by a COVID-19 Vaccine

Keiji Sugiura*, Mariko Sugiura

*Corresponding Author: Keiji Sugiura, Department of Environmental Dermatology & Allergology, Daiichi Clinic, Nittochi Nagoya Bld., 2F, 1-1 Sakae 2, Nakaku, Nagoya, 468-0008, Japan.

Received Date: 06 October, 2021

Accepted Date: 12 October, 2021

Published Date: 18 October, 2021


 Keywords: Allergy; Anaphylaxis; COVID-19; Polyethylene glycol (PEG); Vaccine

Two years have passed since the beginning of the global COVID-19 pandemic. People have been afraid of being severely affected by COVID-19 infection, but we have struggled bravely with this difficult virus. At present, we have no proven therapeutic agents against COVID-19, but one effective weapon against this virus is vaccination. There are various kinds of vaccine against COVID-19; our focus here is on allergic reactions following the BNT162b2 mRNA vaccine. The BNT162b2 vaccine does not use live virus, and this vaccine targets the viral spike protein of COVID-19. This spike protein is necessary for the virus to infect human cells. The mRNA molecules of the viral spike protein are surrounded by lipid nanoparticles attached by Polyethylene Glycol (PEG), which provides stability and increases efficiency [1]. The nanoparticles are unaffected by enzyme actions or treatments of diseases and are available to deliver mRNA to cells [2,3]. Virus spike protein produced under the direction of mRNA in cells can cause immune reactions, and this action produces antibodies against virus spike protein [4].

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