Journal of Oncology Research and Therapy (ISSN: 2574-710X)

case report

A Case Report Series of Renal Cell Carcinoma Patients Treated with Nivolumab and Radiotherapy

Francolini Giulio, Pezzulla Donato, Detti Beatrice*, Muntoni Cristina, Visani Luca, Topulli Juliana, Lo Russo Monica, Grassi Roberta, Becherini Carlotta, Livi Lorenzo

Department of Radiation Oncology, AOU Careggi, Florence, Italy

*Corresponding author: Detti Beatrice, Department of Radiation Oncology, AOU Careggi, Florence, Italy. Email:

Received Date: 26 February, 2018; Accepted Date: 21 March, 2018; Published Date: 29 March, 2018

1.       Abstract

1.1.   Background: Many new targeted agents have represented an advance in management of patients with metastatic renal cell carcinoma (RCC), but the appropriate sequencing and combination of these agents in order to reach the best clinical outcomes is still a matter of debate.

1.2.   Case Series: We present a case series of 3 patients with metastatic RCC. All patients underwent immunotherapy with Nivolumab and showed excellent survival outcomes and with a good toxicity profile. At least one case could represent a possible distant response after radiation therapy (abscopal effect) during immunotherapy

1.3.   Conclusions: Immunotherapy represented an efficient and safe option for treatment of metastatic RCC patients, with excellent outcomes and a possible abscopal effect. Prospective data are needed.

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