Dentistry: Advanced Research (ISSN: 2574-7347)

Case Report

A Palatal Ulcer Might Be the First Sign of Potentially Fatal Diseases - Two Case Reports

Zhexuan Bao,1 Ye Geng,2 Yinxue Shi,2 Hong Bi,3 Ning Cong4,5*

1Department of Oral Medicine, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, China

2Department of Hematology, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, China

3Department of Pathology, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, China

4Department of Otology and Skull Base Surgery of ENT, Eye and ENT Hospital, Fudan University, Shanghai, China

5ENT Institute, Eye and ENT Hospital of Fudan University, Shanghai, China

Corresponding Author*: Ning Cong, Department of Otology and Skull Base Surgery of ENT, Eye and ENT Hospital, Fudan University, ENT Institute, Eye and ENT Hospital of Fudan University, 83 Fenyang Road, Xuhui Distinct, Shanghai, China

Received Date: 24 August, 2021

Accepted Date: 03 September, 2021

Published Date: 07 September, 2021

Abstract

Background: A palatal ulcer is a non-specific clinical presentation and might be the first sign of a potentially fatal disease; thus, accurate diagnosis is challenging.

Case Summary: Here, we present two cases with palatal mucosal ulcers both located on the left side and with similar clinical appearance. Case 1 was diagnosed with pulmonary Tuberculosis (TB) and case 2 was diagnosed with Extranodal NK/T-Cell Lymphoma, nasal type (ENKTCL). Both cases responded well to systemic therapy, and the palatal ulcers completely healed without recurrence.

Conclusion: TB and ENKTCL should be included in the differential diagnosis of palatal ulcer of unknown etiology.

Keywords: Diagnosis; Extranodal NK/T Cell Lymphoma; Palatal Ulcer; Pulmonary Tuberculosis

AbbreviationsCT: Computed Tomography; CRP: C-Reactive Protein; DNA: Deoxyribonucleic Acid; EBV: Epstein-Barr Virus; ENKTCL: Extranodal NK/T Cell Lymphoma, Nasal Type; EBER: EpsteinBarr Virus Encoded RNA; ESR: Erythrocyte Sedimentation Rate; Hb: Hemoglobin; HIV: Human Immunodeficiency Virus; HE: Hematoxylin and Eosin; HE: Hematoxylin and Eosin; ISH: In Situ Hybridization; LDH: Lactate Dehydrogenase; MRI: Magnetic Resonance Imaging; NEUT#: Neutrophil Count; PET/CT: Positron Emission Tomography/Computed Tomography; RNA: Ribonucleic Acid; TB: Tuberculosis; WBC: White Blood Cell