Journal of Neurology and Experimental Neural Science (ISSN: 2577-1442)


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Neural Control of Skin Water Content: The Eccrine Sudoriferous Gland

*University Laval and CHU de Québec, 2705 Laurier Boulevard, Quebec City, QC, Canada.

Laval University/CHU de Québec, 2705 Laurier Boulevard, Quebec City, QC, Canada, G1V 4G2,Tel: +4185254444 (ext.48831); Email:


Received Date: 21 November, 2016; Accepted Date:25November, 2016; Published Date: 28 November, 2016

Citation: Guertin PA (2016) Neural control of skin water content: the eccrine sudoriferous gland. J Neurol Exp Neural Sci 2016: JNENS-117. DOI: 10.29011/JNNS-117. 100017


The skin, thelargest organ of the bodyis composed of severallayers and cellular structures,distinctively controlled by modulatory signals arising from the central, peripheral and autonomous nervous systems (CNS, PNS, ANS). Most of its functions depend significantly upon water content levels of its constitutive layers. The sudoriferous gland has been traditionally associated to sweating and its primary form of coolingin body temperature control in humans. However, there is increasing evidence suggesting that a keyrole in water content modulation and thus in skin moisture is also played by the sudoriferous gland. Dysfunctionsof skin moisture underlie several debilitating dry skin problems such as xerosis, atopic dermatitis, psoriasis, and rosacea. Each sweat gland receives several nerve fibers that branch out into bands of axonssurrounding the individual tubules of the secretory coil. The latter are surrounded by contractile myoepithelial cells that function as a facilitator of secretory product excretion. Evidence from animal studies suggests that efferent signals from the preoptic hypothalamus travel to the pons (tegmentum), the medullary raphe regions,and the intermediolateral cell column of the spinal cord for the control of eccrine sudoriferous glands.This editorial aims at summarizing some of the main findings in neural control mechanisms of normal skin functions – specifically those associated with eccrine sudoriferous gland activity.

2.Eccrine Sudoriferous Gland

2.1 Functional anatomyof the skin:The skin is the largest organ (~2m2)of our body and the first line of defense against external factors. It prevents excessive water content losses and, as such, serves as a lipid-rich structure involved in regulating body temperature. The mammalian skin is composed of four layers – namely the epidermis, basement membrane, dermis and subcutaneous or hypodermis. None of the epidermis sublayers (stratumcorneum or SC, granolosum or SG, spinosum, basal) contains blood vessels per se although the deepest layers are ‘nourished’,so to speak,by diffusion from bloodcapillaries extending to the upper layers of the dermis. [1]. The dermis provides strength and elasticity to the skin through an extracellular matrix composed of collagen fibrils, microfibrils, and elastic fibers, embedded in hyaluronan and proteoglycans [1]. It harbors blood vessels, mechanoreceptors, thermoreceptors and nociceptors that provide the sense of touch, pressure and heatas well as biological fluids released from sudoriferous and sebaceous glands.

2.2 Generalknowledge about neural control of skin functions, water-content and skin health: The sensory roles attributed to skin functions are rather well-described in most textbooks. Cutaneous nerves and sensory elements of the Peripheral Nervous System (PNS) respond to stimuli from the circulation and to emotions (“internal trigger factors”) as well as from peripheral receptors (i.e., mechanoreceptors, nociceptors, thermoreceptors, chemoreceptors) by sendingdirectly or indirectly to the CNS,inputs involvedin sensations (hot/cold, pressure/touch, pain, vibration, chemicals, etc.), vasocontraction, vasodilatation, body temperature regulation, barrier function, secretion, growth, differentiation, cell nutrition, nerve growth, inflammatory and immune responses, apoptosis, proliferation, and wound healing [1]. The inner milieu of our body consists of about 70% water(gender- and age-based differences ranging from 55-75%) whereas surrounding ambient air carries less than 1% water[2]. Consequently, skin water content tends to decrease more or less rapidly through sweating and evaporation and, without normal mechanisms for steady replenishment of skin water content levels, xerosis and other dry skin problemsare bound to be experienced. Two main mechanisms affect water content at the cellular level – 1) water transport from inner layers towards the epidermis and, 2) water transport and evaporation from epidermal layers towards the external environment.

2.3 Water transport from inner layers to the epidermis: Skin hydration levelsare regulated by water transport from inner layers, including from blood vessels, that seek bringing in water towards the dermis and, hence, to the epidermis. In other words, water travels from the deeper skin layers towards outmost skin layers to hydrate cells of the SC –where it is eventually being lost to evaporation. Increasing skin water content is thus achievable through enhanced activity of Aquaporin channels, supported by water-binding molecules such as glycerol, expressed on vascular endothelial cells where it facilitates water exchange and transport between blood and dermis [3].  In other words, body water levels as well as blood volumes, circulating flow levels and regional distribution can significantly affect skin water content levels [4]. Indirectly, neural control of water transport may be achieved through neuroendocrine responses (hypothalamic-pituitary-adrenal axis) that regulate vasodilation and vasoconstriction (i.e., arteriovenous anastomoses [5]). This said,the latter are also controlled by CNS structures such as the raphe nucleus, medulla oblongata, preoptic area, hypothalamus,pons and periaqueductal gray matter [6-9].

2.4 Water transport and evaporation from epidermal layers to the exterior:Although, water content levels vary accordingly to skin layer (70% in SG but 15-30% in SC),reducing water transport towards the outmost layers and increasing water-binding capabilities while reducing evaporation constitute another key mechanism of skin water content regulation [1,10]. A novel role of sudoriferous glands in skin water content has recently been unraveled to achieve that.First of all, human sweat glands are generally divided into two types, the apocrine gland and the eccrine gland.The latter is the primary structure of the skin responsible for thermoregulatory sweating in humans – it isfound over the entire body surface[1]. Their density is an important factor of thermoregulation [11]. Structurally, it consists of a bulbous secretory coil (dermis) leading to a duct (epidermis and skin surface) measuring approximately 2–5 mm in length. Spinal neuronssend their axons to sympathetic ganglia where synapses onto postganglionic nonmyelinated C fibers are found en routeto sweat glandinnervations[1]. Direct recordings of postganglionic skin sympathetic nerve activity, possible in humans, enabled finding that a large fraction of the sympathetic activity during heat stress is essentially sudomotor in nature through acetylcholine release that binds to muscarinic receptors [12,13]. This said, sweating can also occur via exogenous administration of α- or β-adrenergic agonists. Immunochemistry studies have also identified a number of possible peptidesinvolved in neuromodulation of sudomotor activity although their specific role(s) remain(s) unclear (e.g., vasoactive intestinal polypeptide, calcitonin gene-related peptide)[14].

2.5 Concluding remarks:Endogenous mechanisms and external devices designed to avoid excess water evaporation losses may help optimizing the effects of sudoriferous gland secretion on water skin content.Sebum is one way to protect against friction and impervious loss of moisture. Specialized socks (coton) may also help fulfilling similar functions. All in all, increasing evidence suggests that key rolesare played by acetylcholine, muscarinic receptors, some neuropeptides and cutaneous nerves in sudoriferous gland secretion and hence, indirectly, in skin water content through enhanced evaporation given that the latter is controlled. As such,these relatively new control mechanisms may become new targets for the development of innovative CNS and/or PNS products against various types of dry skin problems.In the meantime, science-based, innovative skin care products could be used for temporary stimulation of lipid-rich epidermal layers and stimulation of endogenous water transport mechanisms[15,16].

  1. McGrath JA, Eady RA, Pope FM (2004) Rook's Textbook of Dermatology. Blackwell Publishing pp: 3.1-3.6.
  2. Iozzo RV (2005) Basement membrane proteoglycans: From cellar to ceiling. Nature reviews. Molecular cell biology 6: 646–656.
  3. Beitz E (2004) Aquaporins: Handbook of Experimental Pharmacology. Springerpp: 210.
  4. Papp A, Romppanen E, Lahtinen T, Uusaro A, Harma M, et al. (2005) Red blood cell and tissue water content in experimental thermal injury. Burns 31: 1003-1006.
  5. Krogstad AL, Elam M, Karlsson T, WallinBG (1995) Arteriovenous anastomoses and the thermoregulatory shift between cutaneous vasoconstrictor and vasodilator reflexes.J AutonNervSyst 53:215-222.
  6. Blessing WW, Yu YH, NalivaikoE(1999) Raphe pallidus and parapyramidal neurons regulate ear pinna vascular conductance in the rabbit. NeurosciLett 270:33-36.
  7. Key BJ, Wigfield CC (1994) The influence of the ventrolateral medulla on thermoregulatory circulations in the rat.JAutonNervSyst 48:79-89.
  8. Ootsuka Y, Terui N (1997)Functionally different neurons are organized topographically in the rostral ventrolateral medulla of rabbits. J AutonNervSyst 67:67-78.
  9. Owens NC, Ootsuka Y, Kanosue K, McAllen RM (2002) Thermoregulatory control of sympathetic fibres supplying the rat's tail.J Physiol (Lond) 543:849-858.
  10. Bielfeldt S, Schoder V, Ely U, Van Der Pol A, De Sterke J, et al. (2009) Assessment of Human Stratum Corneum Thickness and its Barrier Properties by In Vivo Confocal Raman Spectroscopy. IFSCC Magazine 12: 1.
  11. Shibasaki M, Wilson TE, Crandall CG (2006) Neural control and mechansims of eccrine sweating during heat stress and exercise.J Applied Physiol100: 1692-1701.
  12. Takahashi N, Nakamura T, Kanno N, Kimura K, Toge Y, et al. (2011) Local heat application to the leg reduces muscle sympathetic nerve activity in human. Eur J ApplPhysiol 111: 22013-11.
  13. Schmelz M, Schmidt R, Bickel A, Torebjork HE, Handwerker HO (1998)Innvervation territories of single sympathetic C fibers in human skin. J Neurophysiol 79: 1653-1660.
  14. Schutz B, Schafer MK, Gordes M, Eiden LE, Weihe E (2015) Satb2-independent acquisition of the cholinergic sudomotor phenotype in rodents. Cell MolNeurobiol 35: 205-216.
  15. Guertin PA (2016) Randomized double-blind study assessing safety and efficacy of SQIN on xerosis in subjects with mobility impairment and paralysis. J Dermatol Clin Res4: 1-5.
  16. Perricone NV(2012) Formulations topiques à base d’acylglutathione. PCT application number WO.

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